Diagnostic Test Fine Needle Aspiration Biopsy (FNAB) Examination on Gold Standard Histopathological Tests for Identification of Colli Lymphadenopathy Patients at RSPAL. Dr. Ramelan Surabaya

Authors

  • Devan Andhika Department of Medical Laboratory Technology, Poltekkes Kemenkes Surabaya, Surabaya, Indonesia
  • Anik Handayati Department of Medical Laboratory Technology, Poltekkes Kemenkes Surabaya, Surabaya, Indonesia https://orcid.org/0000-0001-5478-4646
  • Evy Diah Woelansari Department of Medical Laboratory Technology, Poltekkes Kemenkes Surabaya, Surabaya, Indonesia https://orcid.org/0000-0002-3097-9729

DOI:

https://doi.org/10.35882/ijahst.v3i1.190

Keywords:

Colli Lymphadenopaty, Fine Needle Aspiration Biopsy, Diagnostic test, Histopatology

Abstract

Lymphadenopathy is a common clinical manifestation which requires rapid and accurate diagnosis. Fine Needle Aspiration Biopsy (FNAB) is used as an initial and direct diagnosis in cases of lymphadenopathy, confirmatory diagnosis of colli lymphadenopathy is carried out by histopathological examination. The purpose of this study was to determine the value of the FNAB diagnostic test for lymphadenopathy colli FNAB against the gold standard histopathology of Paraffin Blok for benign and malignant lymphadenopathy, examination data for Colli Lymphadenopathy obtained at RSPAL has never been studied before. This type of research is observational descriptive by taking medical record data (SIM-RS) of patients with lymphadenopathy in the colli region who were examined for FNAB and histopathology at the Anatomical Pathology Laboratory Installation, RSPAL dr. Ramelan Surabaya for the period January 2019 – March 2022. The sample used was selected using the total sampling method, obtained as many as 66 samples that met the inclusion criteria. The results of the FNAB examination were then matched against the histopathological gold standard examination data. Furthermore, the data was processed by 2x2 crosstabulation and diagnostic tests were carried out to determine the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. The results showed that the accuracy of the FNAB diagnostic test was 86.56%, sensitivity 80.48%, specificity 96.15%, positive predictive value 97.05%, negative predictive value 75.75%. In general, it can be stated that the FNAB examination can be a screening diagnostic tool that is easy, fast, relatively affordable and applicable in helping to establish the diagnosis of colli lymphadenopathy.

Downloads

Download data is not yet available.

References

H. Rusmini, R. Ariza, dan N. R. P. Sari, “Characteristics of Lymphadenitis in Hospitalised Patients Bandar Lampung-Indonesia,” Malahayati Int. J. Nurs. Heal. Sci., vol. 2, no. 1, hal. 14–19, 2019, doi: 10.33024/minh.v2i1.1059.

A. Deosthali, K. Donches, M. DelVecchio, dan S. Aronoff, “Etiologies of Pediatric Cervical Lymphadenopathy: A Systematic Review of 2687 Subjects,” Glob. Pediatr. Heal., vol. 6, 2019, doi: 10.1177/2333794X19865440.

D. Horas, “Kesesuaian Gambaran Ultrasonografi Gray Scale Dengan Hasil Biopsi Aspirasi Jarum Halus Dalam Membedakan Limfadenopati Leher Jinak Dan Ganas,” Univ. Hasanudidin Pascasarj. Fak. Kedokt., vol. 1, 2017, [Daring]. Tersedia pada: http://digilib.unhas.ac.id/opac/detail-opac?id=36786.

J. Zhou et al., “Fine needle aspiration cytology for lymph nodes: A three-year study,” Br. J. Biomed. Sci., vol. 73, no. 1, hal. 28–31, 2016, doi: 10.1080/09674845.2016.1144947.

C. C. Göret et al., “Diagnostic value of fine needle aspiration biopsy in non-thyroidal head and neck lesions: A retrospective study of 866 aspiration materials,” Int. J. Clin. Exp. Pathol., vol. 8, no. 8, hal. 8709–8716, 2015.

A. Rani, “Karakteristik Klinis dan Sitopatologi Fine Needle Aspiration Biopsy (FNAB) pada Massa Regio Colli di Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Andalas,” J. Fak. Kedokt. Univ. Andalas 1, hal. 6–9, 2019, [Daring]. Tersedia pada: http://scholar.unand.ac.id/61716/2/2. BAB 1 (Pendahuluan).pdf.

B. Sushama, S. Samir, dan R. C. Sangita, “Diagnostic value of fine needle aspiration cytology in metastatic lymphadenopathy,” Biomed., vol. 35, no. 1, hal. 55–59, 2018, doi: https://doi.org/10.3126/medphoenix.v3i1.20760.

J. T Johnson, “Fine-Needle Aspiration of Neck Masses,” Medscape, hal. 1–12, 2018.

H. A. Domanski, Atlas of Fine Needle Aspiration Cytology. 2014.

M. D. Jeffers, J. Milton, R. Herriot, dan M. McKean, “Fine needle aspiration cytology in the investigation of non-Hodgkin’s lymphoma,” J. Clin. Pathol., vol. 51, no. 3, hal. 189–196, 1998, doi: 10.1136/jcp.51.3.189.

K. Alam, V. Maheshwari, N. Haider, F. Siddiqui, A. Jain, dan A. Khan, “Fine needle aspiration cytology (FNAC), a handy tool for metastatic lymphadenopathy,” Internet J. Pathol., vol. 10, no. 2, hal. 1–7, 2010, doi: 10.5580/1df3.

B. J. Hall, R. L. Schmidt, R. R. Sharma, dan L. J. Layfield, “Fine-needle aspiration cytology for the diagnosis of metastatic melanoma: Systematic review and meta-analysis,” Am. J. Clin. Pathol., vol. 140, no. 5, hal. 635–642, 2013, doi: 10.1309/AJCPWSDDHLLW40WI.

M. Ingolfsdottir, V. Balle, dan C. H. ols. Hahn, “Evaluation of cervical lymphadenopathy in children: advantages and drawbacks of diagnostic methods,” Dan. Med. J., vol. 60, no. 8, hal. A4667, 2013.

D. Daskalopoulou, A. D. Rapidis, N. Maounis, dan S. Markidou, “Fine-needle aspiration cytology in tumors and tumor-like conditions of the oral and maxillofacial region: Diagnostic reliability and limitations,” Cancer, vol. 81, no. 4, hal. 238–252, 1997, doi: 10.1002/(SICI)1097-0142(19970825)81:4<238::AID-CNCR6>3.0.CO;2-L.

K. Chorath dan K. Rajasekaran, “Evaluation and Management of a Neck Mass,” Med. Clin. North Am., vol. 105, no. 5, hal. 827–837, 2021, doi: 10.1016/j.mcna.2021.05.005.

E. K. Dwianingsih et al., “Accuracy of fine needle aspiration biopsy to diagnose lymphadenopathy in Dr.Sardjito General Hospital, Yogyakarta, Indonesia,” J. thee Med. Sci. (Berkala Ilmu Kedokteran), vol. 52, no. 01, hal. 48–59, 2020, doi: 10.19106/jmedsci005201202006.

Delyuzar, Z. Amir, dan D. Suryadi, “Diagnostic accuracy of lymphoma established by fine-needle aspiration cytological biopsy,” IOP Conf. Ser. Earth Environ. Sci., vol. 125, no. 1, hal. 11–14, 2018, doi: 10.1088/1755-1315/125/1/012136.

A. Oehadian, “Pendekatan Diagnosis Limfadenopati,” Cdk-209, vol. 40, no. 10, hal. 727–732, 2013.

J. R. Miliauskas, Lymph Nodes. 2012.

Wiganda, D. Achmad, dan M. Abdurahman, “Akurasi Pemeriksaan Biopsi Aspirasi Jarum Halus (BAJAH) dalam Diagnosis Keganasan Kelenjar Getah Bening Leher,” J. llmu Bedah Indones., vol. 35, no. 2, hal. 18–22, 2007, doi: 10.46800/jibiikabi.v35i2.128.

I. A. E. Putra, I. Sutarga, M. Kardiwinata, N. Suariyani, N. Septarini, dan I. Subrata, “Modul Penelitian Uji Diagnostik Dan Skrining,” Progr. Stud. Kesehat. Masy. Fak. Kedokt. Univ. Udayana, hal. 45, 2016, [Daring]. Tersedia pada: https://simdos.unud.ac.id/uploads/file_pendidikan_1_dir/d204d4a5ad0870a0965416e671a38791.pdf.

A. Bazemore dan D. Smucker, “Lymphadenopathy and Malignancy,” Am. Fam. Physician, vol. 66, no. 11, hal. 2103–2110, 2002, [Daring]. Tersedia pada: www.aafp.org/afp.

A. R. Tumbelaka, “Telaah Kritis Makalah Uji Diagnostik,” Sari Pediatr., vol. 4, no. 2, hal. 98, 2016, doi: 10.14238/sp4.2.2002.98-102.

A. P. Bueno et al., “Accuracy of fine-needle aspiration of lymph nodes: A cancer center’s experience,” Cytopathology, vol. 33, no. 1, hal. 114–118, 2022, doi: 10.1111/cyt.13057.

S. Sastroasmoro dan I. Sofyan, Dasar-dasar Metodologi Penelitian Klinis, 4 ed., vol. 4. Sagung Seto, 2011.

J. Attard, J. Galea, dan A. Betts, “The efficacy of lymph node fine needle aspiration cytology,” Malta Med. J., vol. 27, no. 3, hal. 16–21, 2015.

M. Tuntun, W. Sriwulan, D. Setiawan, dan A. Nuryati, Kendali Mutu. 2018.

M. Underbink, “Evaluation and Management of the patient with a neck mass December 2001,” no. December, hal. 1–9, 2001.

RSUD Prof. Dr. Margono Soekarjo Purwokerto, “Pedoman Pelayanan Instalasi Patologi Anatomi,” hal. 22, 2018.

Y. Houcine et al., “Evaluation of fine needle aspiration cytology in the diagnosis of cervical lymph node lymphomas,” J. Cranio-Maxillo-Facial Surg., 2018, doi: 10.1016/j.jcms.2018.04.024.

N. A. Al-Alwan, A. S. Al-Hashimi, M. M. Salman, dan E. A. Al-Attar, “Fine needle aspiration cytology versus histopathology in diagnosing lymph node lesions,” Eastern Mediterranean Health Journal, vol. 2, no. 2. hal. 320–325, 1996, doi: 10.26719/1996.2.2.320.

Downloads

Published

2023-02-26

How to Cite

[1]
D. Andhika, A. . Handayati, and E. D. . Woelansari, “Diagnostic Test Fine Needle Aspiration Biopsy (FNAB) Examination on Gold Standard Histopathological Tests for Identification of Colli Lymphadenopathy Patients at RSPAL. Dr. Ramelan Surabaya”, International Journal of Advanced Health Science and Technology, vol. 3, no. 1, Feb. 2023.

Issue

Section

Medical Engineering and Technology