Expression of Immunoglobulin G / Immunoglobulin M Typhoid On Neutrophil-Lymphocyte Ratio In Patients At Haji Hospital, Surabaya
DOI:
https://doi.org/10.35882/ijahst.v3i4.289Keywords:
Typhoid Fever, IgM, IgG, NLR.Abstract
Typhoid fever is one of the major bacterial infections worldwide caused by the bacterium Salmonella enterica serovars typhi in humans. The examination used is the rapid Typhoid test. This rapid typhoid test is used to detect antibodies to Salmonella typhi. The purpose of the study was to determine the results of the Neutrophil - Lymphocyte Ratio with various criteria results from the Immunoglobulin G / Immunoglobulin M Test in typhoid fever patients. This type of study is descriptive observational with selective sampling taken. The samples in this study were 28 samples conducted in April 2023 on typhoid fever patients at the Hajj Hospital in East Java Province. This study used the Rapid Typhoid Test Immunochromatography method with positive Widal criteria and supporting examination using Neutrophil–Lymphocyte Ratio (NLR) with Hematology Analyzer tool Fluorescent Flow Cytometry method. Typhoid and NLR rapid test results are processed descriptively in tables and based on percentages. The results obtained from the rapid test were positive IgM of 29%, positive IgG of 11%, positive IgG and IgM of 3%, and negative IgG and IgM of 57%. The average NLR was 4,43% with a median of 2,85. IgG / IgM examination of NLR showed no significant association in typhoid fever patients. It is hoped that this research will be further developed using Salmonella culture examination.
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J. Nugraha, M. Purwanta, and Ilham, “Deteksi IgM Anti Salmonella Enterica Serovar Typhi Dengan Pemeriksaan Tubex Tf Dan Typhidot-M,” J. Biosains Pascasarj., vol. 19, no. 2, pp. 127–147, Aug. 2017.
R. A. Duchenne-Moutien and H. Neetoo, “Climate change and emerging food safety issues: A review,” J. Food Prot., vol. 84, no. 11, pp. 1884–1897, 2021, doi: 10.4315/JFP-21-141.
T. N. Manalu and J. Rantung, “Faktor-Faktor Yang Mempengaruhi Kejadian Demam Tifoid,” J. Penelit. Perawat Prof., vol. 3, no. 4, pp. 837–844, Nov. 2021, [Online]. Available: http://jurnal.globalhealthsciencegroup.com/index.php/JPPP
Dinkes Surabaya, “Statistik 10 Penyakit Terbanyak,” https://dinkes.surabaya.go.id/portalv2/profil/dkk-dalam-angka/statistik-10-penyakit-terbanyak/, 2019.
Maharni, “Identification Of Salmonella typhi To Typhoid Fever Suspect In Malili Public Health Center Marhani,” Voice Of Midwifery, vol. 08, no. 01, pp. 734–743, Mar. 2018.
M. Fifendy, Mikrobiologi, 1st ed. Depok: Kencana, 2017.
I. Fauzi Sabban, E. Magdalena, S. Kusuma Wardani, and I. Noer Wahyuni, “Gambaran Hasil Pemeriksaan Widal Menggunakan Serum dan Plasma EDTA Pada Suspek Demam Tifoid Di Rumah Sakit Umum Daha Husada Kota Kediri,” JUKEKE, vol. 2, no. 1, pp. 39–48, 2023, doi: 10.56127/juk.
A. Takaya, T. Yamamoto, and K. Tokoyoda, “Humoral Immunity vs. Salmonella,” Frontiers in Immunology, vol. 10. Frontiers Media S.A., Jan. 21, 2020. doi: 10.3389/fimmu.2019.03155.
A. Yanti, U. Bahrun, and M. Arif, “Neutrophil / Lymphocyte Ratio in Young Adults,” Clin. Pathol. Med. Lab., vol. 22, no. 2, pp. 105–108, Mar. 2016, [Online]. Available: http://www.indonesianjournalofclinicalpathology.or.id
M. R. E. Wuryandari et al., “Lactobacillus plantarum FNCC 0137 fermented red Moringa oleifera exhibits protective effects in mice challenged with Salmonella typhi via TLR3/TLR4 inhibition and down-regulation of proinflammatory cytokines,” J. Ayurveda Integr. Med., vol. 13, no. 2, Apr. 2022, doi: 10.1016/j.jaim.2021.10.003.
M. Nura Sani, Y. Mohammed, N. Muhammad Sani, B. Abdulkadir, and Y. Ibrahim, “Comparative Studies on The Diagnostic Validity of Widal And Evaluation of Interferon Gamma Response In Patients Investigated For Typhoid Fever,” pp. 1–10, Oct. 2020, doi: 10.21203/rs.3.rs-89772/v1.
R. Renowati and M. S. Soleha, “Hubungan Uji Diagnostik Widal Salmonella typhi Dengan Hitung Leukosit Pada Suspek Demam Tifoid,” Padang, 2019.
Putri Kristanti Astika, Woelansari Evy Diah, and Suhariyadi, “Hubungan Pemeriksaan Rapid Test IgG/IgM Typhoid Positif Dengan Bilirubin Pada Penderita Demam Tifoid Di RSUD Kertosono,” J. Anal. Kesehat. Sains, vol. 9, no. 1, pp. 795–802, Jun. 2020, [Online]. Available: http://journal.poltekkesdepkes-sby.ac.id/index.php/ANKES
Kemenkes, “Pedoman Nasional Pelayanan Kedokteran Tata Laksana Infeksi Dengue Pada Dewasa,” 2020.
E. E. Ella, S. Tijjani, and M. Aminu, “Comparative Widal Reaction for IgG/IgM Complement C3, lymphocyte and Neutrophils Assay in Patients with Suspected Typhoid Fever in Selected Hospitals in Kaduna State, Nigeria,” Nig. J. Pure Appl. Sci, vol. 33, no. 1, pp. 3618–3627, 2020, doi: 10.6084/m9.figshare.12363776.
Nurhidayah Meiwinda Rizky, Arfijanto Muhammad Vitanata, Widodo Agung Dwi Wahyu, and Kholili Ulfa, “Profil Rasio Neutrofil Terhadap Limfosit Pada Pasien Dengan Dugaan Demam Tifoid Di RSUD Dr. Soetomo Surabaya,” J. Ilm. Ilmu Kesehat., vol. 9, no. 1, pp. 38–49, 2021.
Z. Widat, A. Jumadewi, and S. Hadijah, “Gambaran Jumlah Leukosit Pada Penderita Demam Tifoid,” J. Inov. Ris. Ilmu Kesehat., vol. 1, no. 3, Jul. 2022.
S. Farisi, W. A. Setiawan, and Suratman, “Isolation Of Salmonella Typhoid 16s rRNA Gene Fragment Based On Polymerase Chain Reaction (PCR),” J. Ilm. Biol. Eksperimen dan Keanekaragaman Hayati, vol. 7, no. 2, pp. 53–58, Dec. 2020.
S. P. dr. Ni Kadek Mulyantari and Ms. Dr.dr. I Wayan Putu Sutirta Yasa, Laboratorium Pratransfusi Up Date, 1st ed. Denpasar, 2017.
Y. Prasetyaningsih, F. Nadifah, D. Arisandi, and D. D. Saputri, “Identifikasi Immunoglobulin Miu (IgM) Immunoglobulin Gamma (IgG) Anti Salmonela Pada Serum Pasien Demam Tifoid Di Puskesmas Godean Ii, Sleman, Yogyakarta,” Gema Kesehat., vol. 12, no. 2, pp. 79–87, Dec. 2020, [Online]. Available: http://jurnalpoltekkesjayapura.com/index.php/gk
A. Rahma Putri, T. Murtina Lubis, and A. Sayuti, “Jumlah Leukosit Dan Diferensial Leukosit Gajah Sumatera (Etephas maximus sumatranus) Jantan Berdasarkan Tingkatan Umur Di Pusat Latihan Gajah (PLG) Minas Riau,” J. Ilm. Mhs. Vet., vol. 6, no. 2, pp. 57–65, 2022.
Cherly Sarah Philipose and T Umashankar, “The role of haematological parameters in predicting malaria with special emphasis on neutrophil lymphocyte count ratio and monocyte lymphocyte ratio: A single Institutional experience,” Trop. Parasitol., vol. 6, no. 2, pp. 147–150, Jul. 2016.
E. Nur Almatin, E. Diah Woelansari, and Suhariyadi, “Neutrophyl Lymphocyte Ratio (NLR) Value As Inflammation Marker In Ulcer Diabetic Patients With Variation Of Blood Glucose,” Int. Conf. Med. Lab. Technol. , pp. 100–104.
P. Forget, C. Khalifa, J. P. Defour, D. Latinne, M. C. Van Pel, and M. De Kock, “What is the normal value of the neutrophil-to-lymphocyte ratio?,” BMC Res. Notes, vol. 10, no. 1, pp. 1–4, Jan. 2017, doi: 10.1186/s13104-016-2335-5.
Z. Liu, Q. Fan, S. Wu, Y. Wan, and Y. Lei, “Compared with the monocyte to high-density lipoprotein ratio (MHR) and the neutrophil to lymphocyte ratio (NLR), the neutrophil to high-density lipoprotein ratio (NHR) is more valuable for assessing the inflammatory process in Parkinson’s disease,” Lipids Health Dis., vol. 20, no. 1, pp. 1–12, 2021, doi: 10.1186/s12944-021-01462-4
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