Analysis of Images of Neutrophil Lymphocyte Ratio and Bacteria Density Level of Helicobacter Pylori in Tissue in Gastritis Patients
DOI:
https://doi.org/10.35882/ijahst.v2i6.181Keywords:
Neutrophil lymphocyte ratio (NLR), Helicobacter Pylori bacteria, GastritisAbstract
Gastritis is an inflammatory disease that can last for a long time. Helicobacter pylori infection is known as the main cause of peptic ulcer and the most common cause of gastritis. Helicobacter Pylori infection will cause mononuclear (MN) and polymorphonuclear (PMN) cell infiltration and will increase the production of proinflammatory cytokines in the gastric mucosa compared to non-Helicobacter Pylori gastritis. Helicobacter Pylori with histopathological examination diagnosis. This type of research is descriptive observational with purposive sampling data collection technique at the Anatomical Pathology Laboratory Installation, RSPAL dr. Ramelan Surabaya. The data used are the results of a biopsy of 60 samples that were determined as gastritis with histopathological examination of the identification of Helicobacter Pylori bacteria in gastric tissue classified by the level of bacterial density using The Updated Sydney System, as well as haemogram data for complete blood examination to further calculate the neutrophil lymphocyte ratio (NLR). The data were processed using descriptive statistical tests to determine the average neutrophil lymphocyte ratio (NLR). Based on the statistics of the r-Spearman test, the density of Helicobacter Pylori, (Pν = 0.000) below < 0.005 indicates that there is a strong relationship between the neutrophil lymphocyte ratio (NLR) and the density of Helicobacter Pylori bacteria.
Downloads
References
M. Ruggeet al., "Gastric Cancer as Preventable Disease," Clin. Gastroenterol. Hepatol., vol. 15, pp. 1833–1843, 2017, doi:10.1016/j.cgh.2017.05.023.
JJY Sunget al., “Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication,” Gut, vol. 69, no. 9, pp. 1572–1580, 2020, doi:10.1136/gutjnl-2019-319826.
R. Alianto, "Histopathological Diagnosis of Gastritis,"Alianto, R. 'Histopathological Diagnosis of Gastritis', 42(8), pp. 597–600., vol. 42, no. 8, pp. 597–600, 2015.
B. Peleteiro, A. Bastos, A. Ferro, and N. Lunet, “Prevalence of Helicobacter pylori infection worldwide: A systematic review of studies with national coverage,”Dig. Dec. science., vol. 59, no. 8, pp. 1698–1709, 2014, doi:10.1007/s10620-014-3063-0.
KM Fock, “Review article: The epidemiology and prevention of gastric cancer,”Aliments. Pharmacol. ther., vol. 40, no. 3, pp. 250–260, 2014, doi:10.1111/apt.12814.
MM Masyitohet al., “The Effect of Fasting on Health of Stomach Digestion System,” Muhammadiyah Int. Public Health. Med. Proceedings, vol. 1, no. 1, pp. 995–1000, 2021, doi:10.53947/miphmp.v1i1.166.
LY Silaban, "DESCRIPTION OF CHARACTERISTICS OF PATIENTS OF GASTRITIS IN SANTA ELISABETH HOSPITAL, MEDAN, 2018 IN SANTA ELISABETH HOSPITAL, MEDAN," 2019.
F. Yatmi, “Student Diet WithGastritis Involved In Student Organization Activities at Jakarta State Islamic University,” vol. 1, 2017.
C. Dunne, B. Dolan, and M. Clyne, “Factors that mediate colonization of the human stomach by Helicobacter pylori,”World J. Gastroenterol., vol. 20, no. 19, pp. 5610–5624, 2014, doi:10.3748/wjg.v20.i19.5610.
K. Sánchez-Alonzoet al., “In vitro incorporation of Helicobacter pylori into Candida albicans caused by acidic pH stress,” Pathogens, vol. 9, no. 6, pp. 1–10, 2020, doi:10.3390/pathogens9060489.
SH Rampengan, "The Relationship between Helicobacter Pylori and Left Ventricular Ejection Fraction in Acute Myocardial Infarction Patients,"fact. Causes of Stress in Health Workers. And Masy. During the Covid-19 Pandemic, pp. 1–42, 2016, [Online]. Available: http://repo.unsrat.ac.id/1129/.
YK Wanget al., “Diagnosis of helicobacter pylori infection: Current options and developments,” World J. Gastroenterol., vol. 21, no. 40, pp. 11221–11235, 2015, doi:10.3748/wjg.v21.i40.11221.
M. Miftahussururet al., “Diagnostic value of 14C urea breath test for Helicobacter pylori detection compared by histopathology in Indonesian dyspeptic patients,” Clin. Exp. Gastroenterol., vol. 14, pp. 291–296, 2021, doi:10.2147/CEG.S306626.
T. Giza, “Neutrophil Lymphocyte Ratio as a Predictor of Ischemic Stroke Severity Outcomes and Discussion,” vol. 10, no. 2, pp. 217–221, 2019, doi:10.35816/jiskh.v10i2.153.
Y. Atayan and P. Hacisalihoglu, “serum neutrophil / lymphocyte ratio in patients with active chronic gastritis The correlation between tissue Helicobacter pylori severity and the increase in serum neutrophil / lymphocyte ratio in patients with active chronic gastritis .," no. January 2017, 2019.
SA Shamsdinet al., “The importance of TH22 and TC22 cells in the pathogenesis of Helicobacter pylori-associated gastric diseases,” pp. 1–10, 2016, doi:10.1111/hel.12367.
L. Wanget al., “Journal of the Neurological Sciences Neutrophil to lymphocyte ratio predicts poor outcomes after acute ischemic stroke : A cohort study and systematic review,” J. Neurol. Sci., vol. 406, no. August, p. 116445, 2019, doi:10.1016/j.jns.2019.116445.
CP Dixon MF, Genta RM, Yardley JH, “Classification and grading of gastritis. The updated Sydney System,” vol. 20, no. 10, p. 81, 1996, doi:10.1097/0000478-199610000-00001.
D. Ariefiany, AH Hassan, BM Dewayani, and A. Yantisetiasti, “Analysis of histopathological features of chronic gastritis with and without Helicobacter pylori according to the Sydney system,” vol. 23, no. 2, 2014.
L. Pramita, WB Uwan, and MI Kahtan,"DESCRIPTION OF ESOPHAGOGASTRODUODENOSCOPIC EXAMINATION RESULTS IN DYSPEPSIA SYNDROME PATIENTS IN SAINT ANTONIUS PONTIANAK GENERAL HOSPITAL 2015-2016," pp. 3–11, 2016.
P. Sipponen and H. Maaroos, “Chronic gastritis Chronic gastritis,” vol. 5521, 2015, doi:10.3109/00365521.2015.1019918.
FA Dja'far, LI Laksmi, M. Lubis, and GA Siregar, "The Relationship between Helicobacter Pylori Cytotoxin-Associated Gene A (CagA) Positive and Negative with Histopathological Severity of Gastritis,"J. Med. Sch., vol. 52, no. 2, pp. 56–60, 2019.
MJ Parnham, “Reactive oxygen species inflammation and rheumatoid arthritis,”Pharm. Weekbl., vol. 125, no. 21, pp. 529–535, 2020.
M. Macarthur, GL Hold, and EM El-Omar, “Inflammation and Cancer II. Role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy,”Am. J. Physiol. - Gastrointestinal. Liver Physiol., vol. 286, no. 4 49-4, pp. 515–520, 2004, doi:10.1152/ajpgi.00475.2003.
IBK Suardana, "Basic Immunology Dictation of the immune system,"Http://Simdos.Unud.Ac.Id, pp. 1–36, 2017, [Online]. Available: https://simdos.unud.ac.id/uploads/file_ Pendidikan_1_dir/284a0e69155751dc6c459b07f14bc03c.pdf.
A. Jafarzadeh, V. Akbarpoor, M. Nabizadeh, M. Nemati, and MT Rezayati, “Total leukocyte counts and neutrophil-lymphocyte count ratios among helicobacter pylori-infected patients with peptic ulcers: Independent of bacterial CagA status,”Southeast Asian J. Trop. Med. Public Health, vol. 44, no. 1, pp. 82–88, 2013.
Y. Atayan and P. Hacisalihoglu, “The correlation between tissue Helicobacter pylori severity and the increase in serum neutrophil/lymphocyte ratio in patients with active chronic gastritis,”biomed. res., vol. 28, no. 11, pp. 4874–4877, 2017.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Fadia Rakhmalia
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlikel 4.0 International (CC BY-SA 4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).