Identifying Purine Intake Among People with Gout and Its Relationship with Uric Acid Level: A Cross-Sectional Study
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purine-rich food, uric acid levels, hyperuricemia
Abstract
Gout was still one of the chronic disease trends suffered by the community which was characterised by elevated uric acid levels. This condition is closely related to lifestyle, namely the consumption of purine-rich foods. However, there were not studies that discovered the relationship between purine-rich food intake with elevated uric acid levels. This study aims to analyse the relationship between purine-rich food intake with elevated uric acid levels. This study used a correlational design with a cross-sectional approach. The population was the community in village "x" who suffered from gout with a total of 70 people. From them, 66 people were selected as participants who met the inclusion criteria through a purposive sampling method. The instrument used was a questionnaire for the variable of purine-rich food intake and uric acid test with a GCU meter. The results showed that there was a strong positive correlation between purine-rich food intake with elevated uric acid levels (p = 0,000; r = 0,567), this is evidenced by the fact that the majority of participants with high uric acid levels had a history of consuming purine-rich foods exceeding the daily tolerance limit, whereas low or normal uric acid levels were found in participants with a history of consuming high purine foods below the threshold or even not consuming purine-rich foods. These results indicated that consuming purine-rich foods could have a significant impact on elevated uric acid levels, so it was necessary to reduce or limit daily purine food intake.
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References
[1] K. M. Asghari et al., “Gout: global epidemiology, risk factors, comorbidities and complications: a narrative review,” BMC Musculoskelet. Disord, vol. 25, no. 1, 2024, doi: 10.1186/s12891-024-08180-9.
[2] Z. Bowen-Davies, S. Muller, C. D. Mallen, R. A. Hayward, and E. Roddy, “Gout Severity, Socioeconomic Status, and Work Absence: A Cross-Sectional Study in Primary Care,” Arthritis Care Res, vol. 70, no. 12, pp. 1822–1828, 2018, doi: 10.1002/acr.23562.
[3] M. Cross et al., “Global, regional, and national burden of gout, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021,” Lancet Rheumatol, vol. 6, no. 8, pp. e507–e517, 2024, doi: 10.1016/S2665-9913(24)00117-6.
[4] Q. He et al., “Global, Regional, and National Prevalence of Gout From 1990 to 2019: Age-Period-Cohort Analysis With Future Burden Prediction,” JMIR Public Heal. Surveill, vol. 9, pp. 1–19, 2023, doi: 10.2196/45943.
[5] M. D. Russell et al., “Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY,” Lancet Rheumatol, vol. 5, no. 10, pp. e622–e632, 2023, doi: 10.1016/S2665-9913(23)00206-0.
[6] C. Lu et al., “Research hotspots and trends related to pain in gouty arthritis from 2014 to 2024: A bibliometric analysis,” Medicine (Baltimore), vol. 103, no. 46, p. e40525, 2024, doi: 10.1097/MD.0000000000040525.
[7] A. Ginting, M.S.D. Simanullang, and G.A. Sihombing, ”Factor Analysis With The Event Of Gout In The Community Of Lumban Barat Village,” Science Midwifery, vol.10, no.1, pp. 78-84, 2021.
[8] S. Aihemaitijiang, Y. Zhang, L. Zhang, J. Yang, C. Ye, M. Halimulati, and Z Zhang, “The association between purine-rich food intake and hyperuricemia: A cross-sectional study in Chinese adult residents,” Nutrients, vol. 1, no. 6, pp. 3835-3845, 2020.
[9] E.F. Dungga, “Pola makan dan hubungannya terhadap kadar asam urat,” Jambura Nursing Journal, vol. 4, no. 1, pp. 7-15, 2022.
[10] T. Wahyu, “The factors affecting the incidence of hyperuricemia on the Rejang tribe in Bengkulu,” SANITAS: JURNAL TEKNOLOGI DAN SENI, vol. 11, no. 1, pp. 53-64, 2020.
[11] P. Yayu,” HUBUNGAN POLA MAKAN, AKTIFITAS FISIK DAN USIA TERHADAP KEJADIAN PENYAKIT GOUT ARTHTRITIS PADA LANSIA,” Jurnal Mitrasehat, vol. 14, no. 1, pp. 576-584, 2024.
[12] M. Zhou, X. Li. R. Huang, Z. Zhang, L. Zhang, X. Gao, Y. Ma. “Association of dietary patterns with blood uric acid concentration and hyperuricemia in northern Chinese adults,” Nutrition journal, vol. 21, no. 1, pp. 42-48, 2022. https://doi.org/10.1186/s12937-022-00789-7
[13] A. Danve, S.T. Sehra, T. Neogi. “Role of diet in hyperuricemia and gout.” Best practice & research Clinical rheumatology, vol. 35, no. 4, pp. 101723, 2021. doi:10.1016/j.berh.2021.101723.
[14] S. Cheng, L. Shan, Z. You, Y. Xia, Y. Zhao, H. Zhang, Z. Zhao, “Dietary patterns, uric acid levels, and hyperuricemia: a systematic review and meta-analysis,” Food & Function, vol. 14, no.7, pp. 7853-7868, 2023.
[15] W. Piao, L. Zhao, Y. Yang, H. Fang, L. Ju, S. Cai, D. Yu, “The prevalence of hyperuricemia and its correlates among adults in China: results from CNHS 2015–2017,” Nutrients, vol. 14, no. 9, pp. 4095, 2022.
[16] G. Ou, J. Wu, S. Wang, Y. Jiang, Y. Chen, J. Kong, H. Xu, L. Deng, H. Zhao, X. Chen, L. Xu, “Dietary Factors and Risk of Gout: A Two-Sample Mendelian Randomization Study,” Foods, vol. 13, no. 8, pp. 1269, 2024. https://doi.org/10.3390/foods13081269
[17] B. Kong, F. Liu, S. Zhang, Y. Wu, Y. Li, J. Xiong, Y. Tang, Y. Li, P. Yao, “Associations between dietary patterns and serum uric acid concentrations in children and adolescents: A cross-sectional study,” Food Funct, vol. 14, no. 2, pp. 9803–9814, 2023.
[18] M. De Meulemeester, E. Mateus, H. Wieberneit-Tolman, N. Betteridge, L. Ireland, G. Petersen, F. Perez-Ruiz, “Understanding the patient voice in gout: a quantitative study conducted in Europe,” BJGP open, vol. 4, no. 1, pp. 1-9, 2020.
[19] C. Morris, L. Macdonald, M. Stubbe, A. Dowell, “It’s complicated: talking about gout medicines in primary care consultations: a qualitative study,” BMC family practice, vol. 17, no. 4, pp. 1-9, 2016.
[20] D. Webrianti, Y. Yuliarti, “Dietary Insights in Gout Management: A Descriptive Exploration of Eating Patterns,” Proceedings Series on Health & Medical Sciences, vol. 5, pp. 240-245, 2024.
[21] Yan, M., Liu, Y., Wu, L., Liu, H., Wang, Y., Chen, F., ... & Mi, B. (2022). The association between dietary purine intake and mortality: evidence from the CHNS cohort study. Nutrients, 14(9), 1718.
[22] K.Y. Park, H.J. Kim, H.S. Ahn, S.H. Kim, E.J. Park, S.Y. Yim, J.B,” Effects of coffee consumption on serum uric acid: systematic review and meta-analysis,” In Seminars in arthritis and rheumatism, Vol. 45, No. 5, pp. 580-586, 2016.
[23] Y. Zhang, C. Chen, H. Choi, C. Chaisson, D. Hunter, J. Niu, T. Neogi, “Purine-rich foods intake and recurrent gout attacks,” Annals of the rheumatic diseases, vol. 71, no. 9, pp. 1448-1453, 2012.
[24] R. Villegas, Y.B. Xiang, T. Elasy, W.H. Xu, H. Cai, Q. Cai, X.O. Shu, “Purine-rich foods, protein intake, and the prevalence of hyperuricemia: the Shanghai Men’s Health Study,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 22, no. 5, pp. 409-416, 2012.
[25] H. Hariyono, Y. Peristiowati, E. Pujiati, Y. Ti'ani, T. Nusnah, I. Murtiawani, J. Sutrisno, “The Effect Of Consumption Of A High-Purine Diet On Increasing Uric Acid Levels And Blood Pressure In The Elderly In Kediri District,” Journal for Research in Public Health, vol. 6, no. 1, pp. 43-50, 2024.
[26] Y. Zhang, S. Chen, M. Yuan, Y. Xu, H. Xu, “Gout and diet: a comprehensive review of mechanisms and management,” Nutrients, vol. 14, no. 17, pp. 3525, 2022.
[27] Z. Chen, X. Xue, L. Ma, S. Zhou, K. Li, C. Wang, Y. Chen, “Effect of low-purine diet on the serum uric acid of gout patients in different clinical subtypes: a prospective cohort study,” European Journal of Medical Research, vol. 29, no. 1, pp. 449-459, 2024.
[28] T. H. Chiu, C.H. Liu, C.C Chang, M.N. Lin, C.L. Lin, “Vegetarian diet and risk of gout in two separate prospective cohort studies,” Clinical Nutrition, vol. 39, no. 3, pp. 837-844, 2020.
[29] E. Meiyetriani, H. Hamzah, F. Lima, “The prevalence of hyperuricemia and associated factors in Depok,” AVERROUS: Jurnal Kedokteran Dan Kesehatan Malikussaleh., vol. 3, no. 2, pp. 78-88, 2017.
[30] C. Yokose, N. McCormick, H.K. Choi, “The role of diet in hyperuricemia and gout,” Current opinion in rheumatology., vol. 33, no. 2, pp. 135-144, 2021.
[31] Z. Chen, X. Xue, L. Ma, S. Zhou, K. Li, C. Wang, Y. Chen, “Effect of low-purine diet on the serum uric acid of gout patients in different clinical subtypes: a prospective cohort study,” European Journal of Medical Research., vol. 29, no. 1, pp. 449-452, 2024.
[32] W.Z. Zhang, Q. Peng, X.S. Cai, G.L. Jiang, J.J. Huang, L.L. Lu, J.R. Gu, “A study on the correlation between hyperuricemia and lifestyle and dietary habits,” Medicine, vol. 104, no. 5, pp. e41399, 2025.
[33] X.B. Huang, W.Q. Zhang, W.W. Tang, Y. Liu, Y. Ning, C. Huang, T.D. Wang, “Prevalence and associated factors of hyperuricemia among urban adults aged 35–79 years in southwestern China: a community-based cross-sectional study,” Scientific reports, vol. 10, no. 1, pp. 15683, 2020.
[34] N. Ali, S. Mahmood, F. Islam, S. Rahman, T. Haque, S. Islam, F.A. Khanum, “Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults,” Scientific reports, vol. 9, no. 1, pp. 9061-9071, 2019.
[35] J. Timsans, A. Palomäki, M. Kauppi, “Gout and Hyperuricemia: A Narrative Review of Their Comorbidities and Clinical Implications, “Journal of clinical medicine, vol. 13, no. 2, pp. 7616-7626, 2024.
[36] M. Gaubert, T. Bardin, A. Cohen-Solal, F. Diévart, J.P. Fauvel, R. Guieu, F. Paganelli, “Hyperuricemia and hypertension, coronary artery disease, kidney disease: from concept to practice,” International journal of molecular sciences, vol. 21, no. 1, pp. 4066-4076, 2020.
[37] T. Bardin, E. Magnat, P. Clerson, P. Richette, B. Rouchon, “Epidemiology of gout and hyperuricemia in New Caledonia, Joint Bone Spine, vol. 89, no. 2, pp. 105286., 2022.
[38] L. Li, Y. Zhang, C. Zeng, “Update on the epidemiology, genetics, and therapeutic options of hyperuricemia,” American journal of translational research, vol. 12, no. 7, pp. 3167-3172, 2020.
[39] M. Skoczyńska, M. Chowaniec, A. Szymczak, A. Langner-Hetmańczuk, B. Maciążek-Chyra, P. Wiland, “Pathophysiology of hyperuricemia and its clinical significance–a narrative review,” Reumatologia/Rheumatology, vol. 58, no. 5, pp. 312-323, 2020.
[40] C. Chen, “Hyperuricemia–A narrative review,” Tungs' Medical Journal, vol. 16, no. 2, pp. 43-46., 2022.
[41] M. Furuhashi, “New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity,” American Journal of Physiology-Endocrinology and Metabolism, vol. 31, no. 5, pp. E827-E834, 2020.
[42] A.K. So, F. Martinon, “Inflammation in gout: mechanisms and therapeutic targets,” Nature Reviews Rheumatology, vol. 13, no. 11, pp. 639-647, 2017.
[43] L. Li, Y. Zhang, C. Zeng, “Update on the epidemiology, genetics, and therapeutic options of hyperuricemia,” American journal of translational research, vol. 12, no. 7, pp. 3167, 2020.
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