The The   Role   of the   Hormone   Estrogen   on the Recovery of Women During COVID-19 Pandemic: A Systematic Review

Mafatihul Inayah; Titi  Maharrani; Dina  Isfentiani; Siti Mar’atus  Sholikah; Zarinah Binti Abdul  Aziz

doi:10.35882/ijahst.v2i5.98

Authors

Mafatihul Inayah Department of Midwifery, Poltekkes Kemenkes Surabaya, Surabaya, Indonesia
Titi Maharrani Department of Midwifery, Poltekkes Kemenkes Surabaya, Surabaya, Indonesia https://orcid.org/0000-0002-1763-2886
Dina Isfentiani Department of Midwifery, Poltekkes Kemenkes Surabaya, Surabaya, Indonesia https://orcid.org/0009-0009-1360-0041
Siti Mar’atus Sholikah Department of Midwifery, Poltekkes Kemenkes Surabaya, Surabaya, Indonesia
Zarinah Binti Abdul Aziz Diploma in Nursing Programme ,City University Malaysia, Malaysia

DOI:

https://doi.org/10.35882/ijahst.v2i5.98

Abstract

Coronavirus Disease 2019 (COVID-19) is an infectious disease that attacks the respiratory tract and it is known that the female sex shows a higher cure rate than men due to hormonal influences, namely the hormone estrogen. This research aims to conduct a systematic review of the results of the latest research on the effect of the hormone estrogen on the recovery of female with COVID-19. The article search found 1373 articles from 4 electronic databases, namely PubMed, Research Gate, Science Direct, and Google Scholar which were published in 2020-2021 using keywords and the boolean operator AND. Then the articles were selected using the PRISMA Flow Diagram instrument so that 11 articles were obtained that met the inclusion criteria. The eleven articles were then analyzed to assess the quality of the articles using The Joanna Briggs Institute (JBI) instrument. An article that deserves a review if it gets a score of more than 50%. After analyzing the assessment with JBI, 11 articles were declared eligible for review because them get a score of more than 50%. Seven of the 11 articles stated that the hormone estrogen had a significant effect on healing COVID-19, especially in female. Four other articles stated that the hormone estrogen had no significant effect on the recovery of women with COVID-19 due to several influencing factors including age, Body Mass Index (BMI), comorbid diseases, and smoking habits. The hormone estrogen affects the recovery of female with COVID-19 especially in young female, normal BMI, no comorbid, and not smoking. It is necessary to carry out a further literature review on the effect of the hormone estrogen on healing COVID-19 in female by taking into account the number of samples, sample criteria, and measurement of estrogen hormone levels.

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References

Sutaryo, N. Yang, L. Sagoro, and D. S. Sabrina, Buku Praktis Penyakit Virus Corona 19 (COVID-19), vol. 53, no. 9. 2018.

D. O. Acheampong, I. K. Barffour, A. Boye, E. Aninagyei, S. Ocansey, and M. T. Morna, “Male predisposition to severe COVID- 19: Review of evidence and potential therapeutic prospects,” Biomed. Pharmacother., vol. 131, p. 110748, Nov. 2020, doi: 10.1016/j.biopha.2020.110748.

G. Sharma, A. S. Volgman, and E. D. Michos, “Sex Differences in Mortality From COVID-19 Pandemic,” JACC Case Reports, vol. 2, no. 9, pp. 1407–1410, 2020, doi: 10.1016/j.jaccas.2020.04.027.

A. B. Docherty et al., “Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.,” BMJ, vol. 369, p. m1985, May 2020, doi: 10.1136/bmj.m1985.

M. Baratchian et al., “Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes,” Sci. Rep., vol. 11, no. 1, Dec. 2021, doi: 10.1038/S41598-021-90491-1.

L. M. Hilliard, A. K. Sampson, R. D. Brown, and K. M. Denton, “The ‘his and hers’ of the renin-angiotensin system,” Curr. Hypertens. Rep., vol. 15, no. 1, pp. 71–79, Feb. 2013, doi: 10.1007/S11906-012-0319- Y/FIGURES/1.

A. Bukowska et al., “Protective regulation of the ACE2/ACE gene expression by estrogen in human atrial tissue from elderly men,” Exp. Biol. Med., vol. 242, no. 14, pp. 1412–1423, Aug. 2017, doi: 10.1177/1535370217718808.

P. Patrick, P. Ten Eyck, D. K. Meyerholz, S. R. Channappanavar, C. Fett, and M. Mack, “Sex-based differences in susceptibility to severe acute respiratory syndrome coronavirus infection,” Am Assoc Immnol, 2017, doi: 10.4049/jimmunol.1601896.

H. M. Al-kuraishy, A. I. Al-Gareeb, H. Faidah, T. J. Al-Maiahy, N. Cruz-Martins, and G. E. S. Batiha, “The Looming Effects of Estrogen in Covid-19: A Rocky Rollout,” Front. Nutr., vol. 8, p. 82, Mar. 2021, doi: 10.3389/FNUT.2021.649128/BIBTEX.

P. Pagliaro and C. Penna, “ACE/ACE2 Ratio: A Key Also in 2019 Coronavirus Disease (Covid-19)?,” Front. Med., vol. 7, p. 335, Jun. 2020, doi: 10.3389/FMED.2020.00335/BIBTEX.

T. Ding et al., “Potential Influence of Menstrual Status and Sex Hormones on Female Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Cross-sectional Multicenter Study in Wuhan, China,” Clin. Infect. Dis., vol. 72, no. 9, pp. e240–e248, May 2021, doi: 10.1093/cid/ciaa1022.

J. Liu et al., “Association of sex with clinical outcomes in COVID-19 patients: A retrospective analysis of 1190 cases,” Respir. Med., vol. 173, p. 106159, 2020, doi: https://doi.org/10.1016/j.rmed.2020.106159.

Y. Meng et al., “Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients,” PLOS Pathog., vol. 16, no. 4, p. e1008520, Apr. 2020, doi: 10.1371/journal.ppat.1008520.

C. Mussini et al., “Better prognosis in females with severe COVID-19 pneumonia: possible role of inflammation as potential mediator,” Clin. Microbiol. Infect., vol. 27, no. 8, pp. 1137–1144, 2021, doi: https://doi.org/10.1016/j.cmi.2020.12.010.

D. Peruzzu et al., “Synergy Between Vitamin D and Sex Hormones in Respiratory Functionality of Patients Affected by COVID-19.,” Front. Pharmacol., vol. 12, p. 683529, 2021, doi: 10.3389/fphar.2021.683529.

U. Seeland et al., “Evidence for treatment with estradiol for women with SARS-CoV-2 infection.,” BMC Med., vol. 18, no. 1, p. 369, Nov. 2020, doi: 10.1186/s12916-020-01851-z.

G. Zhao et al., “Sex differences in immune responses to SARS-CoV- 2 in patients with COVID-19,” Biosci. Rep., vol. 41, no. 1, Jan. 2021, doi: 10.1042/BSR20202074.

A. Cagnacci and A. Xholli, “Age-related difference in the rate of coronavirus disease 2019 mortality in women versus men,” Am. J. Obstet. Gynecol., vol. 223, no. 3, p. 453, Sep. 2020, doi: 10.1016/J.AJOG.2020.05.039.

L. Erfinanda et al., “Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation,” Eur. Respir. J., vol. 57, no. 1, Jan. 2021, doi: 10.1183/13993003.00921-2020.

Y. Widjayanti, “Gambaran Keluhan Akibat Penurunan Kadar Hormon Estrogen pada Masa Menopause,” Adi Husada Nurs. J., vol. 2, no. 1, pp. 96–101, 2016,[Online]. Available: https://adihusada.ac.id/jurnal/index.php/AHNJ/article/view/41/121.

A. Viveiros et al., “Sex differences in COVID-19: Candidate pathways, genetics of ACE2, and sex hormones,” Am. J. Physiol. - Hear. Circ. Physiol., vol. 320, no. 1, pp. H296–H304, Jan. 2021, doi: 10.1152/AJPHEART.00755.2020.

N. Mishra et al., “COVID-19 and Menstrual Status: Is Menopause an Independent Risk Factor for SARS Cov-2?,” J. Midlife. Health, vol. 11, no. 4, pp. 240–249, Oct. 2020, doi: 10.4103/jmh.JMH_288_20.

J. Sha et al., “Sex Differences on Clinical Characteristics, Severity, and Mortality in Adult Patients With COVID-19: A Multicentre Retrospective Study.,” Front. Med., vol. 8, p. 607059, 2021, doi: 10.3389/fmed.2021.607059.

J. Wang et al., “Sex differences in clinical characteristics and risk factors for disease severity of hospitalized patients with COVID‐19,” MedComm, vol. 2, no. 2, pp. 247–255, Jun. 2021, doi: 10.1002/mco2.66.

F. Raimondi et al., “Covid-19 and gender: lower rate but same mortality of severe disease in women-an observational study,” BMC Pulm. Med., doi: 10.1186/s12890-021-01455-0.

A. Ungurianu et al., “Lipoprotein redox status evaluation as a marker of cardiovascular disease risk in patients with inflammatory disease,” Mol. Med. Rep., vol. 15, no. 1, p. 256, Jan. 2017, doi: 10.3892/MMR.2016.5972.

G. Cai, Y. Bossé, F. Xiao, F. Kheradmand, and C. I. Amos, “Tobacco smoking increases the lung gene expression of ACE2, the Receptor of SARS-CoV-2,” Am. J. Respir. Crit. Care Med., vol. 201, no. 12, pp. 1557–1559, Jun. 2020, doi: 10.1164/RCCM.202003-0693LE/SUPPL_FILE/DISCLOSURES.PDF.

A. R. Saltiel and J. M. Olefsky, “Inflammatory mechanisms linking obesity and metabolic disease,” J. Clin. Invest., vol. 127, no. 1, pp. 1– 4, Jan. 2017, doi: 10.1172/JCI92035